PID tuning is a technique used to stabilize temperature controllers. The extruder heaters and the heated bed in the 3D Labs HTX use PID control.
PID tuning is performed on all heaters in your machine at the factory, however there are certain conditions in which a PID tune is recommended:
The PID tuning wizard in 3D Labs ION will automatically calibrate the heater of your choice, and save the results to the firmware.
Generally you'll want to choose a temperature that is close to the material you'll be working with, but it doesn't have to be to work.